FK-506 therapeutic drug monitoring

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Plasma vs whole blood for therapeutic drug monitoring of patients receiving FK 506 for immunosuppression.

By retrospective analysis of 13,000 blood samples obtained from 248 patients receiving FK 506 therapy, we compared the suitability of plasma with that of whole blood as the matrix for therapeutic drug monitoring of FK 506. The plasma concentrations did not correlate with the concentrations in whole blood (r = 0.56). In contrast to plasma samples (analyzed by enzyme immunoassay), FK 506 was dete...

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FK 506: a new therapeutic agent for severe recalcitrant psoriasis.

BETWEEN 12 and 18 months ago we treated three patients with FK S06 who had severe psoriasis that was refractory to conventionai therapy and four patients with w,despread incidental psonasis before undergoing hean or liver transplantation under FK 506. All had dramatic resolution of psonasis. which remaIned in remission as long as full-dose therapy was provided. Serial skin biopsies had a rapid ...

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ژورنال

عنوان ژورنال: Clinical Chemistry

سال: 1994

ISSN: 0009-9147,1530-8561

DOI: 10.1093/clinchem/40.12.2207